Myokines,Not Metabolites

Now I'm thinking CFS is a hypersensitivity to myokines rather than metabolites. If the metabolites were the culprit, you should be able to walk a distance without the rests by keeping your heart rate below your anaerobic threshold (AT). By definition, AT is the rate at below which metabolites do not accumulate because your body can clear them all as they are produced. CFS patients, however, must take frequent rests even when walking slowly at below their AT rate to prevent post-exertional sickness. That could be because myokines accumulate at lower heart rate than AT.

This also explains why walking even a slightly faster than the safe speed triggers the post-exertional sickness. Slow walk is anti-inflammatory. But it turns pro-inflammatory when you walk faster. The fact that I get a post-exertional sickness after a few squats can be explained likewise.  The paper by Yeo NH et. al. demonstrates the effects of different exercise intensity on myokines.  All these taken together is  yet another reason why measuring exercise type/speed would be more useful than heart rate in predicting the post-exertional sickness.

So, does it matter if CFS patients are sensitive to myokines or metabolites, or sunspot cycles for that matter? For my purpose, no. I am only after managing the fatigue, and therefore how/when of fatigue is all that matters, not what/why. What and why are the job of the scientists. But having a model for the underlying structure, even if that is only my imagination, helps me to figure out when and how of the fatigue. If you have a working model, you will know when things are not going your way. If you don't have one, well, you are just meandering in the wilderness with no direction.