I bought curcumin phytosome from Amazon and started on it a few days ago. This is the same brand used in the CFS trial for its anti-inflammatory property in reducing fatigue. The trial resulted in 15% improvement, so it's not much to write home about. I am not trying it for anti-inflammatory property though. I am more interested in microglial deactivation via TLR4 receptor inhibition and curcumin is supposed to be one of the antagonists.This paper claims that curcumin significantly deactivated microglia in concussion fatigue patients after in vivo injection. Taking orally is not the same thing obviously. Curcumin is famous for low absorption rate and it's not clear how much of what's absorbed actually gets to the brain. But I figure it's worth the try. If nothing, 15% improvement is still nothing to sneeze at.
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